string fileName = "Имя_файла.docx";
wordApp = new Word.Application();
document = wordApp.Documents.Open(fileName);
Word.Bookmarks bookmarks = document.Bookmarks;
bookmarks["Дата"].Range.Text = DateTime.Today.ToShortDateString();
bookmarks["Номер"].Range.Text = "12345";
document.Close();
document = null;
wordApp.Quit();
wordApp = null;