Добрый день, я использовал вот такой варинат {
/ip firewall layer7-protocol
name="anydesk_host" regexp="^.+(anydesk).*\$"
/ip firewall mangle
chain=postrouting action=mark-connection
new-connection-mark=anydesk-conn-mark
passthrough=no layer7-protocol=anydesk_host out-interface-list=WAN log=no
log-prefix=""

chain=prerouting action=mark-routing
new-routing-mark= anydesk-route-mark
passthrough=no connection-mark=anydesk-conn-mart
log=no log-prefix=""
/ip route rule
routing-mark=anydesk-route-mark
action=unreachable