@bot.message_handler(commands=['what'])
def start(message):
markup = types.InlineKeyboardMarkup(row_width=2)
yes = types.InlineKeyboardButton("Да.", callback_data='yes')
no = types.InlineKeyboardButton("Нет.", callback_data='no')
markup.add(yes, no)
bot.send_message(message.chat.id, 'Вопрос?', reply_markup=markup)