Официальный сайт рекомендует следующее:
Telegraf. Full Telegram Bot API support, including games and inline mode.
https://github.com/telegraf/telegraf
Telebot. Easy way to write Telegram bots.
https://github.com/kosmodrey/telebot
Botgram. Microframework to build Telegram bots.
https://github.com/jmendeth/node-botgram
Telegram-node-bot. A node.js module.
https://github.com/naltox/telegram-node-bot
Node-Telegram-bot. A node.js module.
https://github.com/yagop/node-telegram-bot-api
Slimbot. A fuss-free, thin wrapper around Telegram Bot API for Node.js. No frills.
https://github.com/edisonchee/slimbot