Persifox

Запускай не фласк, а Quart - тот же фласк, только async.

Бота через Thead, а Quart в основном потоке.

Примерно так реализовано у меня:

# main.py
bot = NoirBot(debug=True)

thread_bot = threading.Thread(target=bot.run, name="bot")

try:
    thread_bot.start()
    asyncio.run(bot.serve_app())

except Exception as exp:
    lprint(f"Connection failed: {exp}", Color.red)
finally:
    lprint(f"Stopped", Color.yellow)
    exit()

# Bot.py
# Run & Stop funcs
    def run(self) -> None:
        try:
            self.loop.run_until_complete(self.start())
        except KeyboardInterrupt:
            self.node.disconnect()
            self.loop.run_until_complete(self.close())
            # cancel all tasks lingering
        finally:
            self.loop.close()

    def start(self):
        if self._debug:
            return super().start(self._config.get("altsecrets", "token"))
        return super().start(self._config.get("secrets", "token"))

# Bot.py

# App
    async def serve_app(self):
        lprint("Checking routers", Color.blue, worker="APP")

        routersLoad(self)

        lprint("Loading Quart", Color.blue, worker="APP")

        config = hypercorn.Config()
        config.bind = ["0.0.0.0:5001"]
        config.use_reloader = True

        lprint("Done", Color.green, worker="APP")

        await serve(self._app, config)